方向二、淡水鱼类生殖与生长调控

周林燕，女，河南省泌阳县人，特聘教授

1997.09-2004.07 西南师范大学 学士、硕士学位

2004.10-2007.09 日本国立综合研究大学院大学（日本国立基础生物研究所） 博士学位

2007.10-2008.03 日本国立基础生物研究所 博士后研究员

2008.4-2010.3 日本国立基础生物研究所 JSPS博士后研究员

2010.5至今 西南大学生命科学学院 特聘教授

鱼类性别决定、分化的分子机制和分子内分泌学

在鱼类内分泌分子机制领域有创新性研究。同时，在罗非鱼和青鳉性别决定与分化分子机制方面开展了一系列研究工作，并对在性别决定分化和减数分裂过程中有重要作用的基因进行了基因失活和过量表达实验，目前主持和主研课题就集中在这些领域。

先后在《Molecular Endocrinology》、《Endocrinology》、《Journal of Molecular Endocrinology》、《Biochemical and Biophysical Research Communications》、《Fish Physiology and Biochemistry》和《动物学研究》等国内外学术杂志发表学术论文12篇。10余篇论文被SCI收录，相关成果多次在国际学术会议上交流。

1. 周林燕，焦保卫，王德寿. 哺乳动物性别决定机理研究进展[J]. 海南大学学报自然科学版，2003，21：78-84.

2. 周林燕，张修月，王德寿. 脊椎动物性别决定和分化的分子机制研究进展[J]. 动物学研究，2004，25：81-88.

3. Wang DS, Kobayashi T, Zhou LY, Nagahama Y. Molecular cloning and gene expression of Foxl2 in the Nile tilapia, Oreochromis niloticus [J]. Biochem Biophys Res Commun., 2004, 320: 83-89.

4. Liu Z, Wu F, Jiao B, Zhang X, Hu C, Huang B, Zhou L, Huang X, Wang Z, Zhang Y, Nagahama Y, Cheng C, Wang D. Molecular cloning of doublesex and mab-3-related transcription factor 1, forkhead transcription factor gene 2, and two types of cytochrome P450 aromatase in Southern catfish and their possible roles in sex differentiation[J]. J Endocrinol., 2007, 194: 223-241.

5. Wang DS, Kobayashi T, Zhou LY, Paul-Prasanth B, Ijiri S, Sakai F, Okubo K, Morohashi K, Nagahama Y. Foxl2 Up-Regulates Aromatase Gene Transcription in a Female-Specific Manner by Binding to the Promoter as Well as Interacting with Ad4 Binding Protein/Steroidogenic Factor 1[J]. Mol Endocrinol., 2007, 21: 712-725.

6. Zhou LY, Senthilkumaran B, Wang DS, Sudhakumari CC, Kobayashi T, Kobayashi HK, Matsuda M, Yoshikuni M, Nagahama Y. Partial cloning of 17B-HSD1 from the Nile tilapia ovary and its expression pattern during spawning cycle[J]. Fish Physiology and Biochemistry, 2003, 28: 381–382.

7. Zhou LY, Wang DS, Senthilkumaran B, Yoshikuni M, Shibata Y, Kobayashi T, Sudhakumari CC, Nagahama Y. Cloning, expression and characterization of three types of 17beta-hydroxysteroid dehydrogenases from the Nile tilapia, Oreochromis niloticus[J]. J Mol Endocrinol., 2005, 35:103-116.

8. Zhou LY, Wang DS, Shibata Yasushi, Paul-Prasanth B, Suzuki A, Nagahama Y Characterization, expression and transcriptional regulation of P450c17-I and -II in the medaka[J]. Biochem Biophys Res Commun., 2007, 362(3):619-25.

9. Zhou LY, Wang DS, Kobayashi T, Yano A, Paul-Prasanth B, Suzuki A, Sakai F, Nagahama Y. A novel type of P450c17 lacking the lyase activity is responsible for C21-steroid biosynthesis in the fish ovary and head kidney[J]. Endocrinology, 2007, 148(9):4282-91.

10.Wu FR, Zhou LY, Nagahama Y, Wang DS. Duplication and distinct expression patterns of two thrombospondin-1 isoforms in teleost fishes[J]. Gene Expr Patterns., 2009, 9(6):436-443.

11.Zhang WL, Zhou LY*, Senthilkumaran B, Huang BF, Sudhakumari CC, Kobayashi T, Nagahama Y, Wang DS. Molecular cloning of two isoforms of 11beta-hydroxylase and their expressions in the Nile tilapia, Oreochromis niloticus[J]. Gen Comp Endocrinol., 2010, 165(1):34-41 (*:equal contribution)

12.Wang DS, Zhou LY, Kobayashi T, Matsuda M, Shibata Y, Sakai F and Nagahama Y. Dmrt1 repression of aromatase transcription, a possible mechanism favoring the male pathway in tilapia[J]. Endocrinology, 2010, 151:1331-1340.

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