学术带头人

王德寿，男，四川广安人，博士、教授、博士生导师

1981.09-1988.07 西南师范大学学士、硕士

1993.09-1996.07 中山大学博士

1988.06-至今   西南(师范)大学副教授(1993)、教授(1998)、博导(2003)

1998.07-1999.08 以色列Bar-Iran大学博后

1999.09-2000.09 荷兰乌德勒支大学访问学者

2001.06-2001.09 香港中文大学高级访问学者

2001.11-2007.10 日本国立基础生物学研究所合作研究

2009.01-2011.08 任淡水鱼类资源与生殖发育教育部重点实验室副主任

2011.09-至今 任淡水鱼类资源与生殖发育教育部重点实验室主任

2009.01-至今 任重庆市发改委淡水鱼类新品种繁育工程实验室主任

鱼类性别决定与分化和生长调控的分子机制

中国动物学会理事，中国鱼类学会会员，中国水产学会水产生物技术专业委员会委员，重庆动物学会理事长，鱼类生殖和发育教育部创新团队方向带头人，重庆市第一、第二届水产学学术技术带头人。

近年来，对鱼类性别决定与分化有重要作用的芳香化酶基因的表达调控做了开创性的工作，在罗非鱼、青鳉和南方鲇成功克隆了在性别决定和分化中起重要作用的一系列基因和类固醇合成酶，并开展了与这些基因有关的功能研究。在罗非鱼和南方鲇的性别控制方面取得突出成绩。先后主持国家科技部863计划项目、973计划项目、国家自然科学基金重点、国家自然科学基金委员会与香港研究资助局联合科研基金、教育部、农业部重点、948项目和省市课题10余项。

重庆市自然科学一等奖（2010）；

重庆市科技进步一等奖（1998）；

重庆市高等教育教学成果二等奖（2005）。

先后在《Molecular Endocrinology》、《Endocrinology》、《Journal of Molecular Endocrinology》、《Journal of Endocrinology》、《Biology of Reproduction》、《Reproduction》、《Biochemical and Biophysical Research Communications》、《Molecular Reproduction and Development》、《BMC Molecular Biology》、《Molecular and Cellular Endocrinology》、《Gene Expression Patterns》、《General and Comparative Endocrinology》、《Comparative Biochemistry and Physiology》、《Zoological Science》、《Fish Physiology and Biochemistry》、《Journal of Fish Biology》、《Journal of Fish Disease》、《动物学报》、《水生生物学报》和《水产学报》等国内外学术杂志发表学术论文80余篇。30余篇论文被SCI收录，并已被国际学术论文引用500余次，10余篇论文在国际学术会议上交流。

（1）论文：

1.Huang BF, Sun YL, Wu FR, Liu ZH, Wang ZJ, Luo LF, Zhang YG, Wang DS (corresponding author).Isolation, sequence analysis, and characterization of androgen receptor in Southern catfish, Silurus meridionalis. Fish Physiol Biochem. 2010 Dec 29. [Epub ahead of print].

2.Li JZ, Liu ZH, Wang DS, Cheng CHK. 2011. Insulin-like growth factor 3 is involved in oocyte maturation in zebrafish. Biology of Reproduction. 84:476-486. (IF:3.6).

3.Han F, Wang ZJ, Wu FR,Liu ZH,Huang BF，Wang DS (corresponding author). 2010. Characterization, phylogeny, alternative splicing and expression of Sox30 gene. BMC Molecular Biology. 2010，11：98. (IF:2.85)

4.Liu ZH, Zhang YG, Wang DS (corresponding author). 2010 Studies on feminization, sex determination and differentiation of Southern catfish, Silurus meridionalis. Fish Physiology and Biochemistry. 36:223-235. (IF:1.23)

5.Sudhakumari CC, Senthilkumaran B, Raghuveer K, Wang DS, Kobayashi T, Kagawa H, Krishnaiah Ch, Dutta-Gupta A, Nagahama Y. 2010. Dimorphic expression of tryptophan hydroxylase in the brain of XX and XY Nile tilapia during early development. General and Comparative Endocrinology. 166:320-329.

6.Wang DS (corresponding author), Zhou LY, Kobayashi T, Matsuda M, Shibata Y, Sakai F and Nagahama Y. 2010. Dmrt1 repression of aromatase transcription, a possible mechanism favoring the male pathway in tilapia. Endocrinology. 151:1331-1340 (IF:5.3)

7.Zhang WL, Zhou LY, Senthilkumaran B, Huang BF, Sudhakumari C.C, Kobayashi T, Nagahama Y, Wang DS(corresponding author). 2010. Molecular cloning of two isoforms of 11β-hydroxylase and their expressions in the Nile tilapia, Oreochromis niloticus. General and Comparative Endocrinology. 165:34–41. (IF:2.5)

8.Wu FR, Zhou LY, Nagahama Y, Wang DS (corresponding author). 2009. Duplication and distinct expression patterns of two thrombospondin-1 isoforms in teleost fishes. Gene Expression Patterns. 9:436–443 (IF:2.2)

9.Senthilkumaran B, Sudhakumari C C, Wang DS, Sreenivasulu G, Kobayashi T, Kobayashi HK, Yoshikuni M, Nagahama Y.2009. Novel 3beta-hydroxysteroid dehydrogenases from gonads of the Nile tilapia: Phylogenetic significance and expression during reproductive cycle. Molecular and Cellular Endocrinology. 299 : 146–152 (IF:3.0)

10.Wu FR, Zhang XY, Zhang WL, Huang BF, Liu ZH, Hu CJ, Wang DS (corresponding author). 2009. Expression of three gonadotropin subunits in Southern catfish gonad and their possible roles during early gonadal development. Comparative Biochemistry and Physiology part A. 153:44-48. (IF:1.8)

11.de Waal P, Wang D, Nijenhuis W, Schulz R, Bogerd J. 2008 Functional characterization and expression analysis of the androgen receptor in zebrafish (Danio rerio) testis. Reproduction. 136: 225–234. （IF:3.0）

12.Wang DS (corresponding author), Jiao B, Hu C, Huang X, Liu Z, Cheng CH. 2008 Discovery of a gonad-specific IGF subtype in teleost. Biochem Biophys Res Commun. 367:336-341.（IF:3.0）

13.Ijiri S, Kaneko H, Kobayashi T, Wang DS, Sakai F, Paul-Prasanth B, Nakamura M and Nagahama Y. 2008 Sexual Dimorphic Expression of Genes in Gonads During Early Differentiation of a Teleost Fish, the Nile Tilapia Oreochromis niloticus. Biology of Reproduction. 78:333-341.（IF: 3.7）

14.Zhou LY, Wang DS (equal contribution)., Shibata Y, Paul-Prasanth B, Suzuki A, Nagahama Y 2007 Characterization, expression and transcriptional regulation of P450c17-I and -II in the medaka. Biochemical and Biophysical Research Communications 362:619-625. （IF:3.0）

15.Zhou LY, Wang DS, Kobayashi T, Yano A, Paul-Prasanth B, Suzuki A, Sakai F, Nagahama Y 2007 A novel type of P450c17, lacking the lyase activity is responsible for C21-steroid biosynthesis in the fish ovary and head kidney. Endocrinology. 148:4282-4291.（IF: 5.3）

16.Huang XG, Jiao BW, Fung CK, Ho WKK, Zhang Y, Chan CB, Lin HR, Wang DS (corresponding author), Cheng CHK. 2007 The presence of two distinct prolactin receptors in seabream with different tissue distribution patterns, signal transduction pathways and regulation of gene expression by steroid hormones. Journal of Endocrinology. 194:373-392.（IF:3.0）

17.Liu ZH, Wu FR, Jiao BW, Zhang XY, Hu CJ, Huang BF, Zhou LY, Huang XG, Wang ZJ, Zhang YG, Nagahama Y, Cheng CHK, Wang DS (corresponding author)， 2007 Molecular cloning of Dmrt1, Foxl2 and Cyp19 in Southern catfish and their possible roles in sex differentiation. Journal of Endocrinology.194:223-241.（IF:3.0）

18.Wang DS, Kobayashi T, Zhou LY, Paul-Prasanth B, Ijiri S, Sakai F,Okubo K, Morohashi K and Nagahama Y 2007 Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with ad4 binding protein/steroidogenic factor 1. Molecular Endocrinology. 21: 712-725.（IF:5.3）

19.Nakamoto M, Wang DS, Suzuki, A, Matsuda M, Nagahama Y, Shibata N. 2007. Dax1 suppresses P450arom expression in medaka ovarian follicles. Molecular Reproduction and Development. 74:1239-1246. (IF 2.5)

20.Ohmuro-Matsuyama Y, Okubo K, Matsuda M, Ijiri S, Wang DS, Guan G, Suzuki T, Matsuyama M, Morohashi K, Nagahama Y. 2007 Liver receptor homologue-1 (LRH-1) activates the promoter of brain aromatase (cyp19a2) in a teleost fish, the medaka, Oryzias latipes. Molecular Reproduction and Development. 74:1065-1071. (IF 2.5)

21.Nakamoto M, Matsuda M, Wang DS, Nagahama Y, Shibata N. 2006. Molecular cloning and analysis of gonadal expression of Foxl2 in the medaka, Oryzias latipes. Biochemical and Biophysical Research Communications. 344:353-361. (IF 3.0)

22.Oshima Y, Kato T, Wang DS, Murakami T, Matsuda Y, Nagahama Y, Nakamura M, 2006. Promoter Activity and Chromosomal Location of the Rana rugosa P450 Aromatase (CYP19) Gene. Zoological Science. 23:79-85. (IF 1.2)

23.Jiao BW, Huang XG, Chan CB, Zhang L, Wang DS, Cheng CHK (equal contribution of all authors). 2006. The co-existence of two growth hormone receptors in teleost and their differential signal transduction, tissue distribution and hormonal regulation of expression in seabream. Journal of Molecular Endocrinology. 36:23-40. (IF 2.9)

24.Wang DS, Senthilkumaran B, Sudhakumari CC, Sakai F, Matsuda M, Kobayashi T, Yoshikuni M, Nagahama Y. 2006. Molecular cloning, gene expression and characterization of the third estrogen receptor of the Nile tilapia, Oreochromis niloticus. Fish Physiology and Biochemistry, 31: 255-266. (IF 0.7)

25.Matsuda M, Wang D, Nagahama Y 2006. Functional differences between the sex-determining gene of medaka, DMY and DMRT1 which is a paralogous gene of DMY；Zoological Science; 23 (12):1223-1223.

26.Ijiri, S; Wang, D; Nagahama, Y 2006 Gene expression profile in Nile tilapia gonad during sex differentiation.；Journal of Experimental Zoology Part A-Comparative Experimental Biology. 305A(2) : 135-135.

27.Sudhakumari CC, Senthilkumaran B, Kobayashi T, Kajiura-Kobayshi H, Wang DS, Yoshikuni M, Nagahama Y. (2005). Ontogenic expression patterns of several nuclear receptors and cytochrome P450 aromatases in brain and gonads of the Nile tilapia Oreochromis niloticus suggests their involvement in sex differentiation. Fish Physiology and Biochemistry. 31: 129-135. (IF 0.7)

28.Raghuveer K, Rahul G, Wang DS, Bogerd J, Kirubagaran R, Rasheeda MK, Sreenivasulu G, Bhattacharya N, Tarangini S, Nagahama Y, Senthilkumaran B (2005). Effect of methyl testosterone- and ethynyl estradiol-induced sex differentiation on catfish, Clarias gariepinus: Expression profiles of Dmrt1, cytochrome P450aromatases and 3beta-hydroxysteroid dehydrogenase. Fish Physiology and Biochemistry. 31: 143-147. (IF 0.7)

29.Rasheeda MK, Sreenivasulu G, Swapna I, Raghuveer K, Wang DS, Thangaraj K, Dutta-Gupta A, Senthilkumaran B (2005). Thiourea-induced alteration in the expression patterns of some steroidogenic enzymes in the air-breathing catfish Clarias gariepinus. Fish Physiology and Biochemistry. 31: 275-279. (IF 0.7)

30.Zhou LY, Wang DS, Senthilkumaran B, Yoshikuni M, Shibata Y, Kobayashi T, Sudhakumari CC, Nagahama Y (2005). Cloning, expression and characterization of three types of 17-hydroxysteroid dehydrogenases from the Nile tilapia, Oreochromis niloticus. Journal of Molecular Endocrinology. 35:103-116. (IF 2.5)

31.Wang DS, Kobayashi T, Zhou LY, Nagahama Y, 2004. Molecular cloning and gene expression of Foxl2 in the Nile tilapia, Oreochromis niloticus. Biochemical and Biophysical Research Communications 320: 83–89. (IF 3.0)

32.Jiang JQ, Wang DS (equal contribution), Senthilkumaran B, Kobayashi T, Kobayashi HK, Yamaguchi A, Ge W, Young G, Nagahama Y. (2003). Isolation, Characterization and Expression of 11-Hydroxysteroid Dehydrogenase type 2 cDNAs from the Testes of Japanese Eel (Anguilla japonica) and Nile Tilapia (Orechromis niloticus). Journal of Molecular Endocrinology, 31: 305-315 . (IF 3.8)

33.Wang DS, Senthilkumaran B, Kobayashi T, Kajiura-Kobayashi H, Matsuda M, Yoshikuni M, Nagahama Y (2003). Molecular Cloning and Gene Expression of the Riboflavin Binding Protein in the Nile Tilapia, Oreochromis niloticus. Fish Physiology and Biochemistry. 28 : 225-226. (IF 0.7)

34.Fan HG, Wang DS, Kobayashi T, Senthilkumaran B, Sudhakumari CC, Yoshikuni M, Nagahama Y (2003). Molecular Cloning of the Three Gonadotropin Subunits and Early Expression of FSH During Sex Differentiation of the Nile Tilapia, Oreochromis niloticus. Fish Physiology and Biochemistry. 28: 143-144. (IF 0.7)

35.Zhou LY, Senthilkumaran B, Wang DS, Sudhakumari CC, Kobayashi T, Kajiura-Kobayashi H, Matsuda M, Yoshikuni M, Nagahama Y (2003). Partial Cloning of the 17-HSD-I from the Nile Tilapia Ovary and Its Expression Pattern During the Spawning Cycle. Fish Physiology and Biochemistry. 28:381-382. (IF 0.7)

36.Senthilkumaran B, Yoshiura Y, Oba Y, Sudhakumari CC, Wang DS, Kobayashi T, Yoshikuni M, Nagahama Y (2003). Steroidogenic Shift is a Critical Event for Ovarian Follicles to Undergo Final Maturation. Fish Physiology and Biochemistry. 28:313-315. (IF 0.7)

37.Sudhakumari CC, Senthilkumaran B, Kobayashi T, Wang DS, Chang XT, Nagahama Y (2003). Expression of cytochrome P-450 Aromatases in the Sex-Reversed Nile Tilapia. Fish Physiology and Biochemistry. 28:177-178. (IF 0.7)

38.Wang DS, Kobayashi T, Senthilkumaran B, Sakai F, Sudhakumari CC, Suzuki T, Yoshikuni M, Matsuda M, Morohashi K, Nagahama Y. 2002. Molecular cloning of DAX1 and SHP cDNAs and their expression patterns in the Nile tilapia, Oreochromis niloticus. Biochemical and Biophysical Research Communications. 297: 632-640. (IF 3.0)

39.Zhang Yaoguang and Wang Deshou, 1995. Studies on the osteology of the bagrid catfishes from the Jialing River (IV): an approach to the phylogenetic relationship. Journal of Southwest China Normal University (Natural Science). 20(4): 432-439.

40.Wang D.S., H.R. Lin and H. J. Th Goos, 1995. The neuroendocrine regulation of gonadotropin secretion and ovulation in the bagrid catfish, Mystus macropterus . In: Proceedings of the 5th international symposium on reproductive physiology of fish. July 2-8,1995. The University of Texas, Austin, Texas, U.S.A (Edited by F. W. Goetz and P. Thomas. Published by Fish Symposium 95, Austin). P82.

41.Majeed SK and Wang DS, 1994. Tumours in the gonads of the Bagrid catfish Mystus macropterus (Bleeker). Journal of Fish Diseases, 17: 527-532. (IF 1.5)

42.Wang DS et al., 1994. Biological notes on Leiocassis crassilabris (Gunther:Bagridae). Resumes International Workshop on the Biological Bases for Aquaculture of Siluriformes, Montpellier, France, May 24-27,1994. P46.

43.Wang DS, Zhang YG, Luo QS, 1992. Observations on the larval development of Mystus macropterus (Bleeker): Bagridae. Journal of Fish Biology. 40:371-379. (IF 1.5)

44.李明辉，吴风瑞，熊传奇，曾 圣，杨世杰，叶 凯，蒋汶洮，孙运侣，黄宝锋，魏莹莹，焦 静，顾 源，王德寿（通讯作者）. 2011. 尼罗罗非鱼微阵列Fosmid基因组文库的构建及基因筛选. 水产学报. 35（1）：27-34.

45.胡重江，吴风瑞，刘智皓，黄宝锋，张耀光，王德寿（通讯作者）. 2008. 南方鲇Vasa两种亚型cDNA的克隆及其表达研究. 动物学报. 54(6): 1051-1060.

46.张修月，刘智皓，王德寿（通讯作者）. 2008. 南方鲇受精细胞学观察. 四川动物. 27（1）：7-11.

47.黄宝锋，刘智皓，吴风瑞，王德寿（通讯作者）. 2008. 雄激素受体的结构和功能. 四川动物. 27（2）：307-310.

48.徐吉山，王德寿，张耀光. 2007.大鳍鳠卵巢滤泡细胞发育的组织学研究.大理学院学报.6：10-14.

49.章力，黄希贵，焦保卫，吴风瑞，王德寿 (通讯作者). 2006. 南方鲇两种生长激素受体的结构分析及其组织分布和激素调节. 动物学报. 52（6）：1096-1106.

50.吴风瑞，张修月，王德寿（通讯作者）. 2006. 人工诱导南方鲇雌核发育的最适参数.动物学杂志. 41：27-31.

51.刘智皓，张修月，王德寿（通讯作者）. 2005. 脊椎动物基因组与基因复制研究进展[J]. 四川动物. 2005，24(4) ：672-677.

52.章立，黄希贵，王德寿（通讯作者）. 2005. 鱼类胰岛素样生长因子（IGF）系统的研究进展. 动物学杂志. 40（2）：99-105.

53.张修月，焦保卫，吴天利，金灿彪，王德寿. 2005. 南方鲶性腺分化的组织学观察.动物学杂志. 40（1）：41-48.

54.周林燕，张修月，王德寿（通讯作者）. 2004. 脊椎动物性别决定和分化的分子机制研究进展. 动物学研究. 25(1) ：81-88.

55.黄希贵， 焦保卫， 王德寿（通讯作者）. 2004. 生长激素促分泌素受体(GHS-R)的发现及影响.动物学杂志. 39（2）：84-88.

56.邓思平，王德寿（通讯作者）, 张耀光, 焦保卫. 2004. 南方鲶生殖周期中脑垂体和血清促性腺激素水平的含量变化. 西南师范大学学报. 29(4)654-658.

57.邓思平，王德寿（通讯作者），张耀光，吴天利. 2003. LHRH-A和hCG对南方鲶血清促性腺激素水平的影响.湛江海洋大学学报. 23(1):13-16.

58.周林燕，焦保卫，王德寿. 2003. 哺乳动物性别决定研究进展. 海南大学学报. 21（1）： 78-84.

59.邓思平（通讯作者），王德寿，张耀光，吴天利. 2003. 外源激素对南方鲶血清促性腺激素水平的影响. 西南师范大学学报（自然科学版）. 28(4):614-617.

60.邓思平（通讯作者），王德寿，张耀光，吴天利. 2003.诱导南方鲶排卵过程中血清促性腺激素水平的变化. 山地农业生物学报. 22(3):214-217.

61.焦保卫，王德寿，邓思平. 2002. 爬行动物温度性别决定研究进展. 动物学杂志. 35(4) :74-78 .

62.陈细香，金灿彪，徐吉山，王德寿（通讯作者）. 2002. 大鳍鳠消化系统胚后发育的组织学研究. 西南师范大学学报（自然科学版）. 27（2）：239-243.

63.王德寿，林浩然. 2001. 诱导大鳍鳠和长吻鮠排卵过程中血清GTH水平的变化研究. 水生生物学报. 25（2）185-190.

64.邓思平，吴天利，王德寿，张耀光. 2000. 温度对南方鲇幼鱼生长与发育的影响. 西南师范大学学报. 25(6)674-679.

65.王德寿（通讯作者），江宗秀. 2000. 鱼类性外激素的研究进展. 水生生物学报. 24（3）282- 288.

66.王德寿（通讯作者），吴天利，张耀光. 2000. 鱼类性别决定及其机制研究进展. 西南师范大学学报 . 25(3)276-304.

67.王德寿，林浩然，张为民. 1999. 大鳍鱯脑垂体和血清生长激素水平的季节变化. 水产学报. 23（1）：1-5.

68.王德寿，林浩然，蒲德永，张耀光等. 1998. 注射促黄体素释放激素类似物和地欧酮诱导大鳍鱯和长吻鮠排卵的研究. 动物学研究. 19 (3) ：177-183.

69.王德寿，林浩然，H.J.Th. Goos. 1998. 大鳍鱯促性腺激素分泌调控的研究. 动物学报. 44（3）：322-328.

70.王德寿，林浩然，H.J.Th.Goos. 1997. 大鳍鱯脑垂体和血清促性腺激素(GTH)水平的季节变化. 鱼类学论文集(第六辑). 科学出版社(京), 第29-35页.

71.张耀光，王德寿. 1996. 短尾拟鲿分类地位的探讨. 水生生物学报, 20(4):379-382.

72.王德寿，林浩然. 1996. 鲶类生殖内分泌研究. 水产学报. 20(2): 151-158.

73.王德寿，田怀军，蒲德永. 1995. 粗唇鮠生物学的初步研究. 西南师范大学学 报. 20(1): 59-65.

74.张耀光，王德寿. 1995. 嘉陵江鲿科鱼类骨学研究( I )－韦伯氏器的比较. 西南师范大学学报. 20(1): 53-58.

75.张耀光，王德寿. 1995. 嘉陵江鲿科鱼类骨学研究(II)－脊柱及附肢骨的比较. 西南师范大学学报. 20(2): 167-175.

76.张耀光，王德寿. 1995. 嘉陵江鲿科鱼类骨学研究(III)－头骨的比较. 西南师范大学学报. 20(3): 284-292.

77.金灿彪，何学福，王德寿. 1994. 大鳍鱯个体生殖力的研究. 西南师范大学学报. 19(2)：311-315.

78.蒋国福，王德寿. 1993. 家鸡有三个睾丸的解剖记录. 四川动物. 12(1): 42.

79.王德寿，罗泉笙. 1993. 嘉陵江大鳍鱯的年龄和生长的研究. 水生生物学报. 17(2):157-165.

80.龙祥平，王德寿. 1993. 南方鲶仔稚鱼期齿发育的组织学和组织化学. 西南师范大学学报. 18(3): 346-350.

81.龙祥平，王德寿，田怀军. 1993. 南方鲶、大鳍鱯鳔发育的组织学研究. 水产学报. 17(4): 340-343.

82.王德寿，罗泉笙. 1992. 大鳍鱯的繁殖生物学. 水产学报. 16(1): 50-59.

83.王德寿，杨松林. 1992. 大鳍鱯的可量性状、长重关系和肥满度. 西南师范大学学报, 17(4): 510-515.

84.张耀光，王德寿，罗泉笙. 1992. 大鳍鱯的胚胎发育. 西南师范大学学报, 16(2): 223-229.

85.王德寿，罗泉笙，刘少英. 1990. 大鳍鱯头骨形态的观察. 西南师范大学学报. 15(3): 399-404.

86.王德寿. 1987. 南方大口鲶颅骨形态的研究. 西南师范大学学报. （1）130-137.

（2）专著：

何学福, 张耀光主编，王德寿, 洪锡钧, 罗泉笙副主编. 四川经济鲇类研究.西南师范大学出版社. 1998年7月.

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